Anti-inflammatory and analgesic effects of leaves of Chromolaena odorata L. (King and Robinson)
نویسنده
چکیده
This study was to evaluate anti-inflammatory and analgesic effects of the aqueous extract of leaves of Chromolaena odorata (Asteraceae) collected in Brazzaville-Congo. Acute inflammation was induced by using the carrageenan and formaldehyde models, and chronic inflammation by the cotton pellet induced granuloma model. Analgesic effect was evaluated by using the acetic acid-induced writhing, the pressure induced by the analgesymeter as well as the pain induced by formaldehyde. The results obtained show that aqueous extract (400 and 800 mg/kg) inhibits the edema induced by the carrageenan and formaldehyde. Moreover, this extract at the doses used (400 and 800 mg/kg) significantly inhibits granuloma fabric induced by cotton pellet. In addition, aqueous extract (400 and 800 mg/kg) inhibits significantly the pain induced by the three methods used. In conclusion, aqueous extract of C. odorata has anti-inflammatory and analgesic effects. These observations justify the traditional use of this plant in the treatment of inflammatory pathologies and the pain.
منابع مشابه
Chromolaena odorata (L.) : An Overview
Chromolaena odorata is a species of flowering shrub in the sunflower family, Asteraceae. It is native to North America, from Florida and Texasto Mexico and the Caribbean, and has been introduced to tropical Asia, west Africa, and parts of Australia. It is used as a traditional medicine in Indonesia. The young leaves are crushed, and the resulting liquid can be used to treat skin wounds. Accordi...
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